There is another big weekend on tap in Week 5 of the college football season, and the Pac-12 Conference looks to be one of the best in the country this season. One of the most highly-anticipated matchups will take place in Colorado as the Buffaloes are set to host the USC Trojans.

Making NCAAF picks has become just as popular as wagering on the NFL, and there are always great matchups to look at. Betting the spread is one of the best options to look at, but there are other potential betting options to explore as well. Here is some key information that will help you make some Colorado vs USC predictions for this matchup on Saturday.

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Overall Game Info & Outlook

  • USC Trojans vs. Colorado Buffaloes in a big matchup in the Pac-12 Conference. 
  • The USC Trojans are coming into this game as the 8th-ranked team in the country, as they have started off the season by going a perfect 4-0. Colorado has dropped out of the Top 25 after suffering their first loss of the season at Oregon. 
  • This game will be played at Folsom Field in Boulder, Colorado, and another sellout crowd is expected. 
  • Kickoff for this matchup is set for noon ET, and the game will be nationally televised on FOX.

USC Trojans vs Colorado Buffaloes Betting Preview 

USC Trojans

The college football schedule for USC is going to be changing next year as this team will be moving to the Big Ten Conference. That puts some extra pressure on the Trojans to win this year as they want to leave the Pac-12 Conference on top.

It’s been a perfect 4-0 start to the season for the USC Trojans, and they have been blowing teams out along the way. 

  • Despite being 4-0 this season, the USC Trojans are just 2-2 against the spread. 
  • USC has scored at least 42 points in all four games this season and has gone over 55 points three times. 
  • There are some concerns on defense for the Trojans, as they have allowed at least 28 points two times this season.

The college football stats for USC quarterback Caleb Williams are ridiculous again this season, and that’s why he is the favorite to win the Heisman Trophy. Caleb Williams has thrown for 1,200 yards this season to go along with 15 touchdown passes.

USC is a team that wants to throw the football to win games, but at some point, this team is going to need to run the football as well. The Trojans are averaging 192 rushing yards per game, but they have faced some bad defenses.

If the Trojans are going to win this game, then it will be another impressive showing from the offense. USC wants to play fast when they have the football, and they believe that there are some gaps in the Colorado defense. 

Colorado Buffaloes

The hiring of Deion Sanders has transformed this Colorado team, and they were able to get off to a 3-0 start to begin the year. That changed a bit in Week 4 as the Buffaloes were embarrassed on the road at Oregon.

Colorado has now fallen back out of the Top 25 after suffering that loss, and the schedule isn’t going to get any easier. This is going to be a tough matchup for the Buffaloes, but they have to prove they can beat good teams.

  • Colorado scored at least 36 points in each of the first three weeks of the season but managed just six in Week 4.
  • The Buffaloes are 2-2 against the spread this season but failed to cover in each of the last two weeks. 
  • Defense has been an issue for Colorado, as they have allowed at least 35 points in three of their four games. 

Colorado quarterback Shedeur Sanders has thrown for 1,410 yards and 11 touchdowns this season, and he has also taken care of the ball. The Colorado Buffaloes are going to miss Travis Hunter again in this game, and that’s a massive blow for this team. 

The only real chance that Colorado has to win this game is to slow things down when they have the football, and they need the defense to make some big plays. The Buffaloes are not the most talented team in this matchup, and that makes things difficult. 

Playing at home will give Colorado a slight edge in this one, but they are going to need more of an advantage than that.

Let’s take a quick look at the odds before we move on to our Colorado vs USC predictions.

Top Sportsbooks Odds

The college football odds for this matchup set the stage for a potential blowout, but that doesn’t mean the game is going to play out in this manner. You aren’t going to want to even look at the moneyline in this game, as going with the spread is going to be the best way to go.

BetNow: USC Trojans -21.0

BetOnline: USC Trojans -21.5

BetUS: USC Trojans -21.0

Bovada: USC Trojans -21.5

MyBookie: USC Trojans -21.5

USC Trojans vs Colorado Buffaloes Odds & Picks

Odds for this Matchup:

You are going to find the best odds for this matchup at BetUS Sportsbook, and here is a look at the different options to explore:

If you are looking to bet on college football at BetOnline, then you should be leaning heavily toward the visitors in this matchup. Even though Colorado was the talk of college football through three weeks, they have sort of fallen on their face of late.

This game is going to get out of hand pretty early on Saturday, as the Buffaloes will have no answer for Caleb Williams of USC. Colorado isn’t going to lose by over 40 points again, but when making your Colorado vs USC predictions, taking the Trojans at -21.0 is the best wager to make in this matchup.

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