Odds, Picks and Predictions

The Buffalo Bills and Los Angeles Rams prepare to go head-to-head in a Thursday night matchup to kick off the 2022 NFL season. 

The Bills enjoyed a great regular season. They won their division and made a deep playoff run. But they ultimately fell just short. 

But a team that did not fall short was the Los Angeles Rams. LA emerged as Super Bowl champions in a competitive Super Bowl affair against the Bengals. They will begin their journey to repeat on Thursday. 

This projects to be a highly exciting contest between Buffalo and Los Angeles.

Kickoff is scheduled for 8:20 PM EST on Thursday, September 8th, 2022, at SoFi Stadium in Los Angeles, CA. 

Buffalo Bills at Los Angeles Rams Info

Location: SoFi Stadium, Los Angeles, CA

Date: Thursday, September 8th, 2022

Time: 8:20 PM EST


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The Bills enter as narrow road favorites in this game. Buffalo has lofty expectations in 2022, and the oddsmakers believe they have what it takes to get the job done on Thursday. 

But ruling out the Rams is a difficult thing to do. LA has all-around talent and will have confidence following their Super Bowl win. With that being said, there is always the possibility of a championship hangover. 

The 2.5-point spread stands out here. This game, regardless of who comes out on top, is going to be competitive throughout.

Betting Trends

  • The Buffalo Bills were 10-7-2 against the spread last season. 
  • The Los Angeles Rams were 10-11 against the spread last year.
  • The Bills were 5-4 against the spread when playing on the road. 
  • The Rams were 5-6 against the spread when playing at their home field. 
  • Los Angeles was 3-0 against the spread as an underdog last year. 
  • Buffalo was 8-5-2 against the spread as a favorite last year. 
  • The Rams were 1-0 against the spread when playing as a home underdog. 
  • The Bills were 3-2 against the spread when playing as a home favorite. 

The Bills were the better overall team ATS a season ago. But LA was 3-0 when playing as an underdog. 

The Rams certainly are capable of upsetting the odds. They are even more capable of upsetting the odds at their home field. 

But the Bills will come out firing on all cylinders. Their passing attack is great, and the defense will cause havoc for LA.

Betting on Buffalo Bills

The Bills enter this game as the favorites. They could make a huge statement with a Week 1 victory over the defending champs. 

The QB-WR duo of Josh Allen and Stefon Diggs continues to impress. They seem to be on the wavelength with one another and should be in line to give the Rams’ defense a run for their money. LA is going to need to place an immense amount of pressure on Allen if they want to contain him. 

Allen has tallied over 4,400 yards in each of the past two seasons. He’s also recorded at least 36 touchdowns in each of those years. His consistency is extraordinary, and some people believe 2022 may be his best season yet. 

Meanwhile, Diggs posted over 1,200 yards a season ago. He added a career-high ten touchdowns. 

The Bills also feature an elite defense. They can limit both the pass and run. But they will need to be at the top of their game against the Rams. LA can post plenty of points in a hurry. 

The Bills’ success ATS will make them a popular Thursday night betting pick. But are they the right choice?

Betting on Los Angeles Rams

The reigning champion Rams come into this game with a chip on their shoulder. They want to prove that last year was no fluke. So defeating a team as talented as Buffalo out of the gates would send an intimidating message to the rest of the NFL. 

Los Angeles has their own QB-WR duo that is nearly unstoppable. Matthew Stafford and Cooper Kupp enjoyed an incredible 2021 campaign. 

Stafford threw for over 4,800 yards in his first season with the Rams last year. He added 41 touchdown passes and a QB rating of 102.9. 

Kupp broke out in a major way. He found himself in the MVP conversation as a receiver. Kupp tallied over 1,900 passing yards and 16 touchdown receptions. 

Replicating his 2021 success in 2022 will be quite the challenge. But there is no denying the fact that Kupp is one of the NFL’s best wide receivers. 

Aaron Donald anchors the Rams’ defense. Jalen Ramsey’s presence is crucial as well. LA has a sneaky good defensive attack. 

They were overlooked at times last year, but their defense ultimately took care of business when it mattered.

Buffalo Bills at Los Angeles Rams Picks and Predictions

Which team should you place your money on? Can the Rams upset the odds at home, or will the Bills get the job done on the road?

As previously discussed, this is destined to be a close game. It would not be surprising to see a last-second field goal decide the outcome. 

In the end, the Rams are worth taking a chance on. They have the ability to upset the odds in front of their home faithful. LA’s fan base will bring no shortage of energy, which should propel LA to a narrow Week 1 victory.

Expect Josh Allen and the Bills’ offense to post impressive numbers. But the Rams’ defense will do just enough to keep them in check while LA’s offense does the rest. 

The Picks: 

  • Go ahead and take the Los Angeles Rams as your moneyline (straight up) betting selection for this Week 1 matchup
  • Take the under on the implied point total in this one.
  • Roll with the Los Angeles Rams -2.5 with your Thursday night spread betting selection. 

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