The Boston Red Sox at Cleveland Guardians prepare to face off in a Saturday night MLB matchup.

The Best Bets for Saturday, June 25th, 2022

The Cleveland Guardians (36-30) host the Boston Red Sox (40-31) in an American League matchup on Saturday.

Both teams have played well as of late. However, Boston took Game One of this series by a final score of 6-2. It should be noted that the Red Sox were listed as road favorites according to the majority of sportsbooks on Friday.

But Cleveland is the favorite for Game Two. So the Guardians will attempt to cover the spread on Saturday in front of their home fans. Meanwhile, Boston will try to upset the spread on the road.

The first pitch is scheduled for 6:10 P.M. EST on Saturday, June 25th, at Progressive Field in Cleveland, OH.

MLB – Boston Red Sox at Cleveland Guardians MLB Betting Trends

Boston Red Sox:

  • Boston is 39-32 against the run line this season.
  • The Red Sox are 22-13 against the run line on the road.
  • They are 18-10 against the run line as an underdog.
  • Boston is 15-7 against the run line as a road underdog.

Cleveland Guardians:

  • Cleveland is 37-29 against the run line this year.
  • The Guardians are 15-12 against the run line at home.
  • They are 16-13 against the run line as a favorite.
  • Cleveland is 9-7 against the run line as a home favorite.

Betting Odds

Boston Red Sox:

The Red Sox have rebounded nicely following a slow start to the season. They are now third in the AL East and right in the midst of the Wild Card race.

The Red Sox still have some question marks. Their pitching isn’t anything special. Boston would benefit from adding help to the bullpen at the trade deadline.

Despite their lack of big names in the rotation, the Red Sox have produced the sixth-best ERA and WHIP in baseball. So their pitching is outperforming expectations. But its longevity is questionable.

The Red Sox have a strong lineup. Rafael Devers homered on Friday to lead Boston to their victory. The third baseman is enjoying a tremendous 2022 campaign.

Other players such as Xander Bogaerts have stepped up as well.

The Sox are third in batting average, seventh in slugging and seventh in runs scored. This is a ballclub that can score runs in a hurry.

Alex Cora and the Red Sox will turn to Josh Winckowski (2-1, 3.18) on Saturday in Cleveland. He has pitched fairly well for the team this year. Nick Pivetta went seven innings on Friday as well, so the Red Sox bullpen should be well-rested.

Boston has plenty of upset potential in Game Two.

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Cleveland Guardians:

The Guardians are fresh off of an extremely successful road trip. Their competition was challenging on the road, so coming back home with a .500 record would have sufficed. However, the Guards went 7-2 on a road trip that included stops in Colorado, Los Angeles, and Minnesota.

However, they dropped Game One upon their return home on Friday.

Cleveland wasn’t able to produce much offense against Pivetta and the Red Sox in the contest. However, this is a sneak good lineup nonetheless.

The Guardians are 10th in batting average, 17th in slugging, and 16th in runs scored. So they have the ability to cause havoc for opposing pitching staffs.

But Cleveland is the home favorite for a different reason on Saturday. Ace Shane Bieber (3-3, 3.00) is the scheduled starter for the Guardians.

Bieber has bounced back from a rocky 2022 start and is looking like an All-Star yet again. He will certainly have a challenge in Boston’s talented lineup, but he is a pitcher who fares well when his team needs him.

And Cleveland undeniably needs him if they want to even this series up at one game apiece.

Best Betting Odds to Bet Online

How To Bet On: Boston Red Sox at Cleveland Guardians MLB Betting lines

The Guardians enter play as the home favorite with Shane Bieber on the mound. But can Cleveland take care of business against the Red Sox?

Game One was a competitive ball game despite the four-run difference. This is destined to be a good series moving forward. Both teams have seen somewhat similar trajectories this year.

So which team should you place your money on?

OBS Betting Picks for Boston Red Sox at Cleveland Guardians

The Red Sox obviously have upset potential. Their offense is capable of making the best pitchers look bad.

I don’t expect Bieber to completely shut them down, but I think he will keep them at bay.

Meanwhile, the Guardians lineup should be able to score a good amount of runs. They have an experienced pitcher on the mound, and their bullpen may need to work a ton of innings.

Cleveland should be able to enjoy an impressive affair from an offensive standpoint.

And their bullpen should hold down the fort once Bieber exits the game.

Look for the Guardians to come out strong and never look back in Game Two on Saturday.

We should be in for an exciting match, but it is hard to look past the Guardians. Roll with Cleveland -1.5 to earn the victory in this one.

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All odds are courtesy of Betonline.


  • Houston Astros +1.5
  • New York Yankees -1.5

Pick: New York Yankees -1.5

The Yankees and Astros are two of the best teams in MLB. This is an exciting series, without question. Go ahead and roll with New York on Saturday in what projects to be a competitive ballgame.

  • Philadelphia Phillies +1.5
  • San Diego Padres -1.5

Pick: Philadelphia Phillies +1.5

Manny Machado is expected to miss the next few weeks, and he is the backbone for the Padres. As a result, I like the Phillies as a sneaky underdog road pick in this one.

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