Online Betting Sports – Expert Picks, News and Betting Predictions: San Francisco Looks to Regroup After Disappointing 2020 Season.

Following a Super Bowl loss in which they blew a double-digit lead, expectations were high for the San Francisco 49ers to bounce back last year. Those same expectations that never came to fruition last year remain this season.

After dropping six of its final eight games, San Francisco finished last in the NFC West last season with a 6-10 record. 

According to BetUS — one of the top Sportsbooks at Online Betting Sports — the 49ers over/under for wins is projected at.

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Staying Healthy

Although San Francisco underperformed on the field last season, the team had a who’s who list of injured players. Headlining the injury list were Nick Bosa, George Kittle, and Jimmy Garappolo, in addition to Deebo Samuel, Richard Sherman, Dee Ford, Ezekiel Ansah, Raheem Mostert, and Tevin Coleman. 

Garappolo missed the second half of the season, which aided in the 2-6 finish after a modest 4-4 start to the season.

Quarterback Battle

With trading up in the draft in selecting Trey Lance with the No. 3 overall pick, it’s only a matter of time before Jimmy G’s time in San Fran is over, right? Lance has shown flashes of why the team made the move up, but it’s not been nearly enough to unseat Garappolo yet. The best-case scenario for the 49ers and the fans would be a motivated Jimmy G from the start to not only keep the rookie on the bench for the entire season but also lead the team back to glory.

Other Key Players

Of the players listed above who missed significant time last season, all but Sherman and Coleman return this season. 

Trey Sermon was drafted in the third round, which should help bolster the running game, and veteran WR Mohamed Sanu was added to give depth to the receiving corps, which also features a promising young star in second-year WR Brandon Aiyuk.

Having a healthy Kittle for the entire season will also boost the offensive production, no matter who is under center. 

Schedule Breakdown

San Francisco opens the season on the road at Detroit. The 49ers are a 7.5 point favorite with -110 betting odds to cover, according to the folks at BetUS. Bettors wanting to take the safe play with the Moneyline would have to pony up $400 to win $100. 

In NFL Week 3, the ‘Niners host Aaron Rodgers and the Green Bay Packers before opening NFC West play at home against Russell Wilson and Seattle.

After its bye week, San Francisco welcomes Indianapolis to town in Week 7, while the only other non-divisional marquee game comes in Week 16 at Tennessee.

Best for Last?

The last regular-season game could be the most important one. San Francisco travels to Los Angeles to face the Rams with what most likely will be the game that decides who wins the NFC West. 

The game should not only help decide the West, but it will most likely help shape seeding for the playoffs as well.

Last season, the Rams won both matchups by a combined 11 points. 

According to Bovada — another one of the top sportsbooks at — the 49ers (+175) are favored slightly over the Rams (+190) to win the division.


Outside of the ultra-competitive division, the schedule is a favorable one this season for San Francisco. Of course, after last season, staying healthy is going to be a big component, as well as good competition at the quarterback position. There are still some questions on the defensive side of the ball, but the 49ers should not have too much problem hitting the over/under total of wins at 10.5. Winning the division could come down to a tiebreaker with the Rams, in which we have the Rams favorite.

Final 2021-22 Record: 12-5, 2nd in NFC West (lose the tiebreaker to Rams)

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