San Francisco 49ers at Los Angeles Rams NFL Betting Analysis, Odds & Picks

The San Francisco 49ers (9-7) and the Los Angeles Rams (12-4) will go head-to-head in an NFC West showdown on Sunday. Kickoff is scheduled for 1:25 P.M. PST at SoFi Stadium in Los Angeles, CA. 

This is a meaningful game for both sides. 

The 49ers are trying to lock up a Wild Card spot. They took care of business against Houston last week and are now in control of their fate. A New Orleans Saints loss would also guarantee them a playoff spot regardless of what happens in this game against LA. 

The Rams enter Sunday with a one-game lead over the Arizona Cardinals in the NFC West. They can officially clinch the division with a victory over San Francisco or a Cardinals loss. Los Angeles has played great over the last month and a half as they have won five consecutive games leading into Sunday. 

Let’s break down this crucial final game of the regular season between these division rivals. 

Betting Analysis for San Francisco 49ers at Los Angeles Rams NFL 


San Francisco 49ers Betting Stats & Analysis

The 49ers have had a solid yet fairly inconsistent campaign. But one area where consistency has not been an issue is against the Rams. San Francisco has won five consecutive head-to-head matchups with Los Angeles, including a dominating win earlier this season. 

The 49ers just know how to play against the Rams. But this is a Los Angeles team that has played inspired football as of late, so things might be in line to change on Sunday.

The biggest question for San Francisco heading into this game is who will be the starting quarterback?

With Jimmy Garoppolo injured last week, Trey Lance got the start and did not disappoint. The young QB went 16-23 through the air to go along with 249 yards and a touchdown. 

But a recent report stated that Jimmy Garoppolo looked good in practice this past week. Head coach Kyle Shanahan has yet to name the starter, but one would figure that Garoppolo would receive the nod if he is healthy. 

The 49ers did a tremendous job on defense last time they played against Los Angeles. This is a unit that is fifth in passing yards allowed per game and ninth in rushing yards per contest overall this year. If they can limit the Matthew Stafford-Cooper Kupp connection on Sunday, the 49ers could upset the odds on the road. 

The Niners limited Matthew Stafford to just 26-41 passing while intercepting him twice in the last meeting between the teams. The 49ers will look to use that 31-10 win over Los Angeles as confidence heading into this matchup. 

Los Angeles Rams Betting Stats & Analysis

The Rams kryptonite has been the 49ers over the past couple of seasons. Can they overcome their past struggles and rebound with a victory at home on Sunday?

Los Angeles is in the midst of a five-game winning streak entering this final week of the season. During that stretch, they defeated quality teams such as the Cardinals and Ravens. This is a team on a mission, and they will not let past history stand in their way of defeating the Niners on Sunday. 

Last week, the Rams narrowly escaped with a hard-fought 20-19 victory against Baltimore. Stafford threw for over 300 yards and added two touchdowns, while MVP candidate Cooper Kupp added six receptions for 95 yards and a touchdown. 

The win was a true test of character for the Rams. They were not playing their best, yet they were still able to hold on and get the job done. 

Los Angeles will have plenty of momentum as they look to wrap up the NFC West against their rivals in this game. 

San Francisco 49ers

  • San Francisco is 8-8 ATS this season. 
  • The 49ers are 4-4 ATS following a win. 
  • They are 4-4 ATS on the road. 
  • San Francisco is 1-1 ATS as an underdog. 
  • The 49ers are 0-1 ATS as an away underdog. 
  • They are 1-4 ATS in divisional games. 
  • San Francisco is 5-3 SU on the road. 
  • The 49ers are 1-1 SU as an underdog. 

Los Angeles Rams:

  • Los Angeles is 8-8 ATS this year. 
  • The Rams are 5-6 ATS following a victory. 
  • They are 4-3 ATS at home. 
  • Los Angeles is 6-8 ATS as a favorite. 
  • The Rams are 3-3 ATS as a home favorite. 
  • They are 3-2 ATS in divisional games. 
  • Los Angeles is 5-2 SU at home. 
  • The Rams are 10-4 SU as a favorite.

San Francisco 49ers at Los Angeles Rams NFL Betting Odds

Betonline has the Rams listed as 4-point favorites for Sunday’s game. 

BetUS favors Los Angeles by 4.5 points at home against San Francisco. 

Where to find the Best Betting Odds to Bet Online?

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How To Bet On: San Francisco 49ers at Los Angeles Rams NFL – Betting lines

The San Francisco 49ers have dominated the Los Angeles Rams as of late. However, I believe that will end on Sunday in LA. The Rams are looking like a legitimate title contender right now, and they certainly have the ability to win this game and clinch the division. 

While this projects to be a competitive and exciting matchup between two talented teams, expect the Los Angeles Rams to cover the spread and emerge victorious on Sunday at home against the 49ers. 

OBS Betting Picks for San Francisco 49ers at Los Angeles Rams NFL


Take the Los Angeles Rams -4 with your NFL betting selection.  

Now that you have all the information you need to place an informed bet, it is time to start increasing your income.

Pick up the best sports betting site, sign up and make your bet on the San Francisco 49ers and Los Angeles Rams NFL game on Sunday, January 9th, 2022.

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