Odds, Picks and Predictions

The 49ers and Broncos both started off the season with losses. San Francisco lost on the road in Chicago, while Denver dropped a close game in Seattle. 

San Francisco was able to rebound with a win against the Seahawks. The Broncos bounced back against the Texans with a victory as well. 

But now only one of them can have a record of over .500. This should be a good game in Denver.

The San Francisco 49ers (1-1) and Denver Broncos (1-1) will prepare to face off on Sunday. 

Kickoff is scheduled for 8:20 PM EST on Sunday, September 25th, at Empower Field in Denver, CO. 

San Francisco 49ers at Denver Broncos Info

Location: Empower Field, Denver, CO

Date: September 25th, 2022

Time: 8:20 PM EST


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Betting Trends

  • The San Francisco 49ers are 1-1 against the spread this season. 
  • The Denver Broncos are 1-1 against the spread this year.
  • The Broncos are 0-1 against the spread when playing at home. 
  • The 49ers are 0-1 against the spread when playing on the road.
  • Denver has no record against the spread as an underdog this year. 
  • San Francisco is 1-1 against the spread as a favorite this year. 

The 49ers enter this game as the favorites. Despite playing on the road, San Francisco is viewed as the team to beat heading into this matchup. 

The Broncos and 49ers have had similar seasons up to this point. They both certainly feature a number of strengths and weaknesses throughout their respective rosters. 

Both the Broncos and 49ers are 1-1 against the spread overall so far in 2022. However, the Broncos are 0-1 ATS at home, and the 49ers are 0-1 ATS on the road. 

It will be interesting how they both fare on Sunday in Denver. Let’s take a closer look at each team.

Betting on San Francisco 49ers

The 49ers had mixed results last week. They defeated the Seahawks 27-7 at home. However, Quarterback Trey Lance went down with an injury. 

As a result, Lance is expected to miss the remainder of the season. The QB won the starting job out of camp, but now Jimmy Garoppolo will take over QB duties. 

Garoppolo finished the game 13-21 with a touchdown and 154 passing yards. Jeff Wilson Jr helped matters out of the backfield. He recorded 84 rushing yards in the affair. 

The 49ers’ defense did a tremendous job of keeping pressure on Seattle all game long as well. They picked off Geno Smith once and sacked him twice. 

It will be interesting to see how the Niners perform this season with Jimmy G leading the charge. They were successful last season with Garoppolo under center, but he came up short in the playoffs. However, his veteran experience will benefit the team. 

On the season, the 49ers are now 19th in points scored per game, 18th in total yards per game, 31st in passing yards per game, fourth in rushing yards per game, and second in time of possession per contest. 

Defensively, they are first in total yards against per game, first in passing yards surrendered per game, and second in rushing yards per game. 

The defense and rushing attack has gotten the job done so far. If they continue to perform well, the 49ers will be fine moving forward.

Betting on Denver Broncos

The Broncos escaped with a narrow 16-9 victory over Houston last week. But Denver did not give us any reason to trust them in this competitive win over the lackluster Texans. 

Russell Wilson went just 14-31 through the air with a 66.5 QB rating. He finished with 219 passing yards to go along with one touchdown and one interception. 

Javonte Williams rushed for 75 yards out of the backfield. Melvin Gordon III added 47 rushing yards. 

Courtland Sutton stood out from a receiving perspective. He reeled in seven receptions on 11 targets. 

But this Broncos offense has yet to find their rhythm. It may be due to the fact that Russell Wilson is still finding his footing with the team. They should figure things out sooner rather than later.

But one has to wonder how much potential Denver’s offense actually has.

The defense limited Houston’s offense. Without their strong defensive effort, Denver probably loses this game. 

The Broncos’ defense is now ranked third in points allowed per game, third in total yards per game, fifth in passing yards allowed per game, and fifth in rushing yards per game. 

Meanwhile, Denver’s offense is 24th in points per game, seventh in total yards per game, eighth in passing yards per game, 10th in rushing yards per game, and sixth in time of possession per game. 

San Francisco 49ers at Denver Broncos Picks and Predictions

Which of these teams should you roll with? Will the 49ers cover the very narrow spread, or can the Broncos upset the odds at home?

When betting on the spread, you are practically betting on the moneyline given the extremely competitive spread. That is something bettors need to keep in mind before placing their final bets.

This game will likely be decided by how well the Broncos’ offense plays. With the 49ers, we know what to expect. Jimmy Garoppolo is steady, albeit unspectacular. 

But Russell Wilson is capable of going off at any given moment. It would not be surprising to see Denver’s offense break out in a major way. With that being said, their recent string of play makes them an untrustworthy betting pick. 

I expect this game to come down to the wire. In the end, the 49ers should be able to take care of business.

 The Picks: 

  • Go ahead and take the San Francisco 49ers as your moneyline (straight up) betting selection for this game. 
  • Take the under on the implied point total in this one.
  • Roll with the San Francisco 49ers -1.5 with your Sunday NFL spread betting selection.

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