Week 6 of the NFL season is filled with some great games, but most NFL fans aren’t excited for what will take place on Sunday night. The New York Giants are set to visit the Buffalo Bills, and there is a massive spread in this game. 

Even though the Bills are big home favorites over their in-state rivals in this game, that’s not the only way to look at this matchup. Here is a look at some Bills vs Giants best picks for this Week 6 matchup on Sunday Night Football.

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Overall Game Info & Outlook

New York Giants vs Buffalo Bills

Location: Highmark Stadium, Orchard Park, NY

Date & Time: October 15th at 8:20 PM ET. 

How to Watch: NBC

It has been a miserable start to the season for the Giants as they have gone just 1-4 to begin the year. The New York Giants schedule only gets tougher from here as well, as they are looking to snap a three-game losing streak. The Bills have gone 3-2 through their first five NFL games, including a loss in Week 5. Buffalo is still a team you will see at the top of the NFL power rankings.

New York Giants vs Buffalo Bills Betting Preview

New York Giants Preview

The New York Giants have a pair of Super Bowl titles this century, but they have also had some difficult times. New York was a playoff team a season ago, and they were expected to be a playoff contender this season as well.

Things haven’t worked out that way for the Giants, as they have gotten off to a 1-4 start to the year. New York has dropped three straight games, and they are dealing with a ton of injuries that are going to impact their ability to win games.


  • The Giants have scored 16 or fewer points in their four losses this season.
  • New York has failed to cover the spread in any of their games this season.
  • Betting the under has been the play, as the Giants have played in four games that have been under the total. 

The New York Giants are led by quarterback Daniel Jones, and he does a little bit of everything for this team. Jones has thrown for just 884 yards this season, but he has also picked up 197 yards on the ground.

New York could actually be without Jones in this game, and they are still without running back Saquon Barkley. That is going to create some serious issues on the offensive side of the ball and make it hard for the Giants to score any points. 

The defense for New York has been a major issue as well, and that unit is going to have to step up and play their best game of the year. If the Giants are going to find a way to win this game on Sunday night, then they will have to play sharp and create some turnovers. 

Buffalo Bills Preview 

The Buffalo Bills have had solid Super Bowl odds in recent years, but they always seem to come up short in the playoffs. Buffalo was a big favorite to win the AFC East this season, but they are currently looking up at the Miami Dolphins in the NFL standings. 

There is still plenty of time for Buffalo to turn things around, and getting some momentum by picking up a big win in this game is going to be key. 


  • The Bills come into this game having scored at least 37 points in three games this season.
  • Buffalo has gone 3-0 ATS in their three outright wins this season. 
  • The over has hit in each of the three Bills wins this season, while the under has hit in each loss.

Bills quarterback Josh Allen has thrown for 1,407 yards and 11 touchdowns this season, and Stefon Diggs continues to be his top target. Diggs has 39 receptions for 520 yards and five touchdowns, and he is always a threat to score when he is on the field. 

The Bills are an elite offensive team, but they need this defense to step up and start to play well also. Buffalo is allowing 352 yards this season, and that’s too many for a team that wants to be elite. 

If Buffalo is going to win this game, then they will be trying to speed up the tempo on both sides of the ball. The Bills have the ability to be one of the best NFL teams this season, and they are going to be looking to show off all of their talent in this game.

Top Sportsbooks Odds

Explore the latest odds from top sportsbooks for the Bills vs Giants matchup with our Bills vs Giants Best Picks.

BetNow: Buffalo Bills -14.5

BetOnline: Buffalo Bills -14.5

BetUS: Buffalo Bills -14.5

Bovada: Buffalo Bills -14.5

MyBookie: Buffalo Bills -14.5

New York Giants at Buffalo Bills Odds & Picks 

Odds for this Matchup: 

If you are going to bet on the NFL at BetUS, then there are plenty of other betting odds to look at for this matchup. Here is a look at the NFL odds for this Sunday Night Football showdown:

If you are going to make NFL picks, then you have to look closely at both teams in this matchup. It’s pretty clear that the Bills are the better overall team in this game, but that doesn’t mean that they are going to roll in this game.

The Giants are a proud team, and they will be doing all that they can to keep this game close on Sunday Night Football. Buffalo will eventually pull away, but covering 14.5 points is not easy. 

When making your Bills vs Giants best picks, take the 14.5 points and bet on the New York Giants for this matchup on Sunday night.

  • Pick: Giants Spread at +14.5.

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