The Kansas City Chiefs (4-2) and San Francisco 49ers (3-3) will butt heads on Sunday. 

Kansas City dropped a competitive 24-20 affair against the Buffalo Bills last week. The Chiefs almost got the job done but ended up falling short. Nevertheless, it is always exciting football when the Chiefs and Bills face off. 

The Niners were upset by the Atlanta Hawks by a final score of 28-14 last week. The 49ers entered the game expected to emerge victorious but were plagued by turnovers in the defeat. 

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Kickoff is scheduled for 4:25 PM EST at Levi’s Stadium in San Francisco, CA. 

Kansas City Chiefs at San Francisco 49ers: Facts & Trends

  • The Kansas City Chiefs are 2-4 against the spread this season. 
  • The San Francisco 49ers are 3-3 against the spread this year.
  • The Chiefs are 2-1 against the spread when playing on the road. 
  • The 49ers are 2-0 against the spread when playing at their home field. 
  • Kansas City is 1-3 against the spread as a favorite this year.

Kansas City Chiefs at San Francisco 49ers: Game Info & Odds

Location: Levi’s Stadium

Date: October 23rd, 2022

Time: 4:25 PM EST


Kansas City Chiefs-145O/48.5-2.5
San Francisco 49ers+125U/48.5+2.5

The Chiefs are favored to win on the road. Kansas City has taken a couple of brutal losses this year, but they have looked sharp for the most part. They are once again in line to make another deep playoff run. 

Going into San Francisco and winning is never an easy task, regardless of the team. The Niners feature a strong home environment and will give the Chiefs all that they can handle. But can the Niners upset the odds at home?

Kansas City Chiefs at San Francisco 49ers: Betting Previews

Betting on Kansas City Chiefs

The Chiefs competitive 24-20 loss last week stung. Patrick Mahomes did all he could to help KC emerge victorious.

The KC QB went 25-40 through the air with 338 passing yards and a pair of touchdowns. However, the Bills’ defense and Mahomes threw a couple of interceptions.

The Chiefs’ defense played fairly well and contained the Bills’ potent offense to an extent. But Josh Allen and Co. still performed well and earned the win. 

The Chiefs enter this Week-7 matchup with the 49ers seeking redemption. They come into the game ranked first in points per game, fifth in total yards per game, fourth in passing yards per game, and 20th in rushing yards per game. 

The Chiefs’ offense would truly be lethal if they could get a bit more out of the rushing attack. Clyde Edwards-Helaire has been solid, but they would benefit from quality depth. 

Defensively, the Chiefs are 25th in points against per game, 20th in total yards against per game, 13th in total sacks, and 28th in interceptions. Kansas City’s defense has been quite bad in 2022. 

They will try and quiet the Niners on Sunday on the road.

Betting on San Francisco 49ers

The 49ers simply did not play well in all facets of the game against the Falcons. Turnovers told the story, and the defense did not help matters. 

Jimmy Garoppolo was picked off twice in the affair. He added two touchdowns and just under 300 yards, but the turnovers were both costly. 

Jeff Wilson Jr. also lost a fumble out of the backfield in the game. San Francisco did not get much production out of their running game, which placed more pressure on Garoppolo and the passing game. 

The defense allowed Marcus Mariota to throw two touchdowns while going an extremely efficient 13-14 through the air. 

The 28 points allowed were shocking, given their defensive numbers on the year. The 49ers rank second in points against per game, first in total yards against per game, second in sacks, and 12th in interceptions. 

Offensively, they are 19th in points per game, 21st in total yards per game, 22nd in passing yards per game, and 12th in rushing yards per game. 

The Niner offense has been mediocre for most of the year. However, the defense had been elite for the most part, but one has to wonder how they will fare against the powerful Chiefs after getting carved up by Atlanta. 

One would imagine that they will rebound in front of the home fans. Then again, containing Patrick Mahomes and Kansas City is one of the most difficult challenges in the NFL

Injury Report

For the Chiefs, Trent McDuffie, Blake Bell, and Justyn Ross are on the IR. Besides those players, this is a healthy Chiefs team heading into Week 7. They are hoping to keep things that way moving forward.

For the 49ers, Javon Kinlaw and Emmanuel Moseley were recently placed on the IL. Meanwhile, Colton McKivitz sprained his MCL two weeks ago and was placed on the IL. San Francisco has a number of injury concerns as well.

Kansas City Chiefs at San Francisco 49ers: Picks & Predictions

The Chiefs are favored but can they cover this narrow spread?

Kansas City is expected to win, but the Niners are destined for a rebound following their horrendous Week 6 effort. This could wind up being a close game. 

However, Kansas City should be able to pull out the victory near the end of the contest and, given the narrow spread, rolling with them on both the moneyline and spread is the best betting strategy.

 The Pick

  • Go ahead and take the Kansas City Chiefs as your moneyline (straight up) betting selection for this game. 
  • Take the under on the implied point total in this one.
  • Roll with the Kansas City Chiefs -2.5 with your Sunday spread betting selection. 

For more info on NFL odds, NFL betting lines and NFL point spreads, be sure to check out the links below:

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