Check out our betting preview and prediction for the Sunday Night Football match between the Indianapolis Colts and San Francisco 49ers.

Colts Travel West for Sunday Night Football

San Francisco (2-3) is in a rut right now, losers of three straight while struggling to find any consistency on either offense or defense.

Indianapolis (2-4) visits Levi Stadium for Sunday Night Football in a very similar boat, in 2nd place in the AFC South only because that division features 1-5 Houston and 1-5 Jacksonville.

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Betting Odds & Betting Lines

Looking at the BetUS moneyline betting odds, San Francisco 49ners are coming into the match as the favorites, priced at -180, while Indianapolis Colts are at +160 to take the W.

It’s hard to favor either team in NFL Week 7, but 49ers backers get a little bit more value at Bovada, where the line is SF -3.5 compared to BetUS, who has the number at -4. San Francisco is also coming off their bye, which should give them a little more of an edge.

For those interested in totals betting, the line is currently set at 42.5 points.

Colts Playing Better Than Record Indicates

It was a tough start to the season for Indianapolis, who was trying to make the QB transition from Phillip Rivers to Carson Wentz. The Colts started the year 0-3 but also played some pretty good competition in the Seahawks, Rams, and Titans.

Over the last three games, the Colts have looked better, making them intriguing getting the +4.00 points. Indianapolis has beaten Miami 27-17, went to OT in a loss at Baltimore (31-25), and last Sunday played their best game of the season in a 31-3 domination of the Texans.

The Colts still have their work cut out for them up against a rested San Francisco team this week. RB Jonathan Taylor was huge last week for the Colts, running for 145 yards on just 14 carries with two TDs. The 49ers do a good job of shutting down the pass (216.6 ypg) but are a bit more vulnerable vs. the run (113.2), meaning Taylor should be the workhorse again.

Wentz completed just 11 passes last week, but two of those went for TDs to Parris Campbell and Mo Alie-Cox. Wentz has thrown just one interception on the season and has multiple TDs in each of the last three games.

Garoppolo Back for San Francisco

To their credit, the 49ers played well in their last game, a 17-10 loss at Arizona in NFL Week 5. The 49ers held the Cardinals to 210 yards passing and 94 on the ground but still couldn’t get the win over their division foe, mostly due to their own offensive ineptitude.

Rookie Trey Lance was at QB for the injured Jimmy Garoppolo against the Cardinals, but he went just 15 for 29 for 192 yards with 0 TD and 1 INT. Lance injured his knee and is out for Sunday’s game, putting Garoppolo back under center for the meeting with the Colts’ #11 scoring defense (21.8 ppg).

Inconsistency at QB is one of the reasons it’s somewhat strange to see San Francisco as a -4 point favorite. Garoppolo is completing 66% of his passes this season but has just 5 TD to 2 INT on the year. The 49ers did run for 152 yards last game, but 89 of those also came from the mobile Lance.

Colts at 49ers Pick

San Francisco has a couple of advantages this week – they are at home and coming off a bye. Otherwise, there’s not much to be excited about at QB; the running game takes a hit with Lance injured,

The Colts hung with the Ravens in Baltimore, are starting to get better play from Wentz, and are running downhill behind a massive offensive line and with a very solid RB in Jonathan Taylor. Maybe the Colts don’t win this one, but with the betting lines being over a field goal taking the points looks to be the way to go.

If you are looking to bet online, the best NFL pick you can make for this game is taking the Colts +4.00.

Betting Pick: Colts +4

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