Betting On San Francisco 49ers At Arizona Cardinals Pointers & Tip-Offs

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The Niners have won two NFL games in a row heading into this contest. San Francisco is in the midst of a fairly mediocre campaign, but they have the talent necessary to heat up quickly. San Francisco is 3-2 over the course of their past five games overall.

The Cardinals’ 2022 season has been less than stellar. However, they are fresh off a win over the Los Angeles Rams, earning a 27-17 victory over L.A. 

This should be a competitive affair, with the Cardinals aiming to utilize their home-field advantage. 

Kickoff is scheduled for 8:15 PM EST on Monday, November 21st, at Estadio Azteca in Mexico City. Let’s take a look at the odds, trends, and predictions for this contest. 

Overall Game Info & Outlook

  • San Francisco 49ers at Arizona Cardinals
  • Estadio Azteca Stadium, Mexico City
  • Monday, November 21st
  • Kickoff is scheduled for 8:15 PM EST

Betting Backdrops Per Team

San Francisco 49ers Overview: 

The 49ers come into this fair playing an inspired brand of football as of late. Their offense has seen steady improvement while the defense continues to impress. If the defense holds up their end of the bargain on Monday, SF will find themselves in a good position to earn a victory.

However, playing on the road will make things difficult for them. 

  • The San Francisco 49ers are 4-5 against the spread this year.
  • San Francisco is 3-4 against the spread when playing as a favorite in 2022. 

The 49ers are beginning to prove that they are a true contender. Yes, they are just 3-2 over their past five games. But their two-game win streak has impressed and displayed their all-around potential. 

The Niners defeated the Rams 31-14 two games ago. The win was a dominant one, as San Francisco electrified on both offense and defense in the contest. 

They followed that up with another solid win against the Chargers. That victory saw their defense play well once again, while the defense did enough to earn a competitive victory. 

The Niners are expecting to get the job done against Arizona, but the Cardinals are a team more than capable of pulling off an upset. 

On the season, the 49ers rank 18th in points per game, 12th in total yards per game, 13th in passing yards per game, and 13th in rushing yards per game. 

Defensively, they rank fourth in points against per game, first in total yards against per game, eighth in passing yards against per game, second in rushing yards against per game, fifth in sacks, and 14th in interceptions. 

Their defense has obviously set the tone in 2022. The Niners feature an incredible ability to wreak havoc for opposing QBs while containing rushing attacks. 

The offense faces question marks at times, but the duo of Christian McCaffrey and Deebo Samuel is a turning point when they are both healthy.

Arizona Cardinals Overview:

The Cardinals have seen lackluster results in 2022. But they looked sharp in their recent 27-17 win over the Rams. Overall, they are 2-3 over the course of their last five games. 

Arizona is aiming to upset the odds on Monday. It will be interesting to see how they fare in this neutral game location. 

  • The Arizona Cardinals are 5-5 against the spread so far this season. 
  • The Cardinals are 4-3 against the spread as an underdog in 2022. 

The Cardinals need to find some form of consistency. They have tended to look like a completely different team on a week-to-week basis. 

One important thing to note is that Kyler Murray is listed as questionable for the contest. Murray has not enjoyed a terrific season, but his status will play a pivotal role in determining the outcome of this game. 

For Arizona, their offense has held them up this year. 

The Cardinals rank 13th in points per game, 16th in total yards per game, 16th in passing yards per game, and 19th in rushing yards per game. 

Defensively, Arizona is just 30th in points against per game, 23rd in total yards against per game, ninth in rushing yards against per game, 23rd in passing yards against per game, 22nd in sacks, and 14th in interceptions. 

Arizona’s offense may need to lead them to this win. The Niners’ offense is decent, but they won’t dominate opponents. As a result, the Cardinals’ defense may be able to give them a chance in this affair. 

If Arizona can put some points on the board, this game has the potential to be interesting. With that being said, trusting in the Cardinals is a difficult thing to do, given their all-around inconsistency.

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San Francisco 49ers at Arizona Cardinals: Odds & Picks

Odds for this Matchup:

San Francisco 49ers-8-366O/43
Arizona Cardinals+8+296U/43

An 8-point spread is fairly large for this game. But the 49ers’ recent string of play suggests that they have what it takes to potentially cover the spread. 

This game will ultimately be decided by the Cardinals’ offense. If Arizona’s offense can break through against the Niners’ strong defensive unit, there will be a chance for the upset.

Which team should you place your money on? Can the Niners cover the spread as the favorite, or will the Cardinals get the job done?

This could be a close game which would obviously favor Arizona’s chances of covering. But the Niners are an easier team to trust on Monday. San Francisco has given us reason to believe they can earn the win in a convincing fashion. 

Take the San Francisco 49ers at -8 as your main spread betting selection. Just make sure you check out the NFL standings and the NFL scores to make a balanced, informed wagering decision.

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