St. Louis Cardinals at Milwaukee Brewers Odds, Picks, and Predictions

The NL Central is once again up for grabs as the St. Louis Cardinals and Milwaukee Brewers split the first two games of a four-game set. The division is even between the two, and it’s a good pitching matchup going at 8:10 p.m. ET on Wednesday as savvy veteran Adam Wainwright meets Eric Lauer.

Corbin Burnes and the backend of the Brewers bullpen was lights out in Monday’s 2-0 win. Nolan Gorman was the difference in Tuesday’s 6-2 win as he hit two home runs and drove in three as the Cardinals evened the series.

St. Louis Cardinals at Milwaukee Brewers Match Info

Location: American Family Field, Milwaukee, Wisconsin

Date: Wednesday, June 22, 2022

Time: 8:10 p.m. ET

TV: Bally Sports Midwest, Bally Sports Wisconsin

Cardinals at Brewer Matchup

St. Louis Cardinals at Milwaukee Brewers Odds

Odds are listed in moneyline, run line and over/under order:

  • BetOnline – Cardinals -108, Brewers -102; Cardinals -1.5 (+155), Brewers +1.5 (-175); 8.5
  • Bovada – Cardinals -115, Brewers -105; Cardinals +1.5 (-170), Brewers -1.5 (+145); 8.5
  • MyBookie – Cardinals -115, Brewers -105; Cardinals +1.5 (+150), Brewers -1.5 (-180); 8.5
  • BetUS – Cardinals -111, Brewers +101; Cardinals +1.5 (-210), Brewers -1.5 (+175); 8.5
  • BetNow – Cardinals -103, Brewers -107; Cardinals +1.5 (-210), Brewers -1.5 (+175); 8.5

These are weird odds with it nearly being a pick ‘em. The biggest discrepancy that jumps out if you’re wanting to bet on the Cardinals is to take them at MyBookie, where they are +150 to lose by one or win outright. That’s better than the -115 moneyline they’re offering.

As for moneyline odds, BetNow has the best Cardinals odds at -103, and BetUS has the best Brewers odds at +101. 

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Betting Trends

Bettors are split when betting against the spread, though 55% are on the under so far. Over the last 10 games, each team has won five, and the over is 4-6 in those games. In matchups in Milwaukee, the Cardinals have won seven of the last 10.

Cardinals Finding Firepower

The St. Louis offense has shown great depth through injuries and all to maintain a top 5 offense. They are scoring 4.89 runs per game, and their .254 average ranks fourth in baseball. They only strike out 7.63 times per game, which ranks fourth as well.

Paul Goldschmidt, who is facing a back injury, is the National League’s Most Valuable Player frontrunner while hitting .339 with 22 doubles, 16 home runs, 58 RBIs, and 48 runs scored. Tommy Edman leads the team with 55 runs scored while hitting .279 with 10 doubles, three triples, and seven home runs. Nolan Arenado has 15 doubles and 13 home runs, driving in 46 runs. Harrison Bader has 14 extra-base hits, rookie Nolan Gorman is hitting .280 with six home runs in 93 at-bats. The lineup also has a good mix of speed, with Edman and Bader leading the team with 15 stolen bases apiece.

The pitching has been solid, too, allowing 3.98 runs per game, which ranks sixth. There is some cause for concern because opponents are hitting .242 (17th) with an OPS of .701 (16th), and the Cardinals average the fourth-fewest strikeouts per game (7.33). The fear is there will be a regression in allowing more runs because of the volume of baserunners.

The 41-year-old Wainwright hopes to curb that for at least one more night. He’s 5-3 with a 3.06 ERA. St. Louis is 7-3 when he starts, and the over is 6-4 in those starts. One of those losses includes a 4-3 loss to the Brewers on May 26, in which he allowed four runs (three earned) on 10 hits across five innings.

The backend of the bullpen has been very good, with Giovanny Gallegos, Genesis Cabrera, Andre Pallante, and Ryan Helsley all sporting 2.70 ERAs or better. Helsley and Gallegos have combined for 14 saves in 19 opportunities.

Brewers Pitching Key

Starting pitching has been the key for Milwaukee all season long, though they regressed during a recent eight-game losing streak. However, they’ve since won five of the last seven games to create this week’s battle atop the NL Central.

Lauer hopes to get back on track. He is 5-2 with a 3.57 ERA and 72 strikeouts across 68 innings. Though during three straight starts where the Brewers lost, he surrendered 14 runs (11 earned) and did not go more than six innings in a start.

He’s been part of a staff that is 12th, allowing 4.21 runs per game. They should be slightly better, though, with a .233 batting average against, ranking 10th, and opponents having a .679 OPS, ranking ninth. They also strike out 9.45 batters per game, ranking third. Remarkably, they’ve already used 21 pitchers.

The backend is lights out with Devin Williams and Josh Hader. Williams is 5 for 5 in save opportunities and is 2-0 with a 2.33 ERA. He has 44 strikeouts in 27 innings. Hader, who has missed some time on the inactive list, has 20 saves in 21 opportunities and a 0.87 ERA, only surrendering two solo home runs. He has 34 strikeouts in 20.2 innings pitched.

It has been a struggle offensively, though, and the 4.41 runs per game, which ranks 17th, is actually better than where they probably should be. Their .232 batting average is 24th, but they have an OPS of .706, which is 14th. They also strike out 8.95 times per game, ranking 24th.

Christian Yelich is finally getting going out of the leadoff spot, upping his average to .235. Rowdy Tellez is powering the team with 16 doubles, 10 home runs, and 39 RBIs. Hunter Renfroe has 13 home runs, and shortstop Willy Adames has 14 bombs.

St. Louis Cardinals at Milwaukee Brewers Picks and Predictions

  • The lines slightly favor the Cardinals on first release, but it is basically a toss-up. It’s 
  • The over is 6-4 in both Wainwright’s and Lauer’s 10 starts. That could mean it evens back out, or it could be a pattern. Still, both have been solid, and it feels runs will be hard to come by.
  • If Goldschmidt can make his return from a back injury — he’s listed as questionable — that would give the St. Louis offense a lift, especially against the lefty. It would give the Cardinals one less hole to fill with Tyler O’Neill and Yadier Molina out indefinitely. If Lauer can lock in like early in the season and get six innings out of him, the Brewers should be able to bridge to the backend and reclaim the NL Central lead. We’ll take Milwaukee +101.

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