Odds, Picks and Predictions

The St. Louis Cardinals (66-51) travel to Arizona to take on the Diamondbacks (55-63) in a National League matchup on Friday night.

The Cardinals are fresh off of a 13-0 victory over the Rockies in St. Louis. St. Louis swept Colorado in a three-game set and have now won four consecutive games. They will look to keep rolling in this series in Arizona. 

Meanwhile, the Diamondbacks split a four-game series with the Giants in San Francisco. After dropping the first two games, Arizona came roaring back to win the last two games of the series. 

Arizona enters this game as the underdogs despite their home-field advantage. They will attempt to upset the odds against the NL Central-leading Cardinals. 

The first pitch is scheduled for 9:40 PM EST on Friday, August 19, 2022, at Chase Field in Arizona.

St. Louis Cardinals at Arizona Diamondbacks Info

Location: Chase Field, Phoenix, Arizona

Date: Friday, August 19th, 2022

Time: 9:40 PM EST


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The Cardinals have played an impressive brand of baseball as of late. They are in a good position to cover the run line in this game. 

But the Diamondbacks are playing in front of their home fans in this game. One would imagine that on a Friday night, the fans will come out in full force. So Arizona may be able to edge out St. Louis based on energy alone. 

However, it is unlikely. Let’s take a closer look at this ball game. 

Betting Trends

  • The St. Louis Cardinals are 66-51 against the run line so far this season. 
  • The Arizona Diamondbacks are 69-49 against the run line so far this year.
  • The Cardinals are 30-26 against the run line when playing on the road. 
  • The Diamondbacks are 35-26 against the run line when playing at their home ballpark. 
  • Arizona is 53-33 against the run line as an underdog this year. 
  • St. Louis is 35-29 against the run line as a favorite this year. 
  • The Diamondbacks are 21-12 against the run line when playing as a home underdog. 
  • The Cardinals are 13-11 against the run line when playing as a road favorite.

Betting on Arizona Diamondbacks

The Arizona Diamondbacks would love nothing more than to send their fans home happy with a Friday night victory. But it will be a difficult challenge given the way that the Cardinals have been playing. 

However, bettors will notice Arizona’s strong against the run line records this season. They are 20 games over .500 in terms of covering the run line outright. 

Additionally, they have fared well against the run line at the home and as an underdog. As sad as it is to say, the Diamondbacks have grown used to being counted out. They understand what it takes to cover run lines and upset the odds. 

Winning, on the other hand, has been the issue. They currently sit in fourth place in the NL West and are over 25 games out of first place. But they are 6-4 over the course of their last ten games. 

So they have played fairly well as of late. Nevertheless, trusting them is a difficult thing to do, given their overall struggles. 

Offensively, they rank 26th in batting average, 23rd in OBP, 17th in slugging percentage, 18th in runs scored, and 14th in home runs. Arizona’s offense is near the bottom of the league overall, but they’ve shown signs of life over their past few games. 

The Diamondbacks defeated the Giants 5-0 on Wednesday. 

Pitching-wise, the Diamondbacks are 21st in ERA, 18th in WHIP, 11th in home runs, and 18th in batting average against. 

Tommy Henry (2-1, 4.15) is the scheduled starter for AZ on Friday to open this series. 

Betting on St. Louis Cardinals

The St. Louis Cardinals trailed the Brewers for most of the season in the NL Central through July. But they have begun to change the narrative and gain momentum in the division over the past few weeks. St. Louis now owns a three-game lead over Milwaukee in mid-August.

The Cardinals are also in the midst of a four-game winning streak. Their pitching and offense has been extremely impressive during that span. They have scored at least five runs in each of those games, and the pitching has surrendered a combined total of eight runs.

They are firing on all cylinders at the moment.

St. Louis has also been productive from a betting standpoint. Their 66-51 against the run line record stands out without question.

The Cardinals are within the top 10 in all of baseball in batting average, OBP, slugging percentage, and runs scored. Meanwhile, they are 11th in home runs. So this offense has what it takes to continue winning moving forward.

Pitching-wise, they are 14h in team ERA, 16th in WHIP, seventh in home runs, and 17th in batting average against.

The Cardinals will send Miles Mikolas (9-9, 3.44) to the mound for this matchup.

St. Louis Cardinals at Arizona Diamondbacks Picks and Predictions

So which team should you place your bets on?

The Cardinals are the obvious favorites in this game. They have played well over the past couple of weeks and are taking care of business on both sides of the baseball right now.

Both the Cardinals and Diamondbacks have done well against the run line. I wouldn’t give either side a huge advantage in that department.

So it comes down to rolling with the better team. And St. Louis is clearly the better ball club. They also are rolling with Miles Mikolas, who provides them with a pitching matchup advantage.

The Cardinals are the pick to click on Friday in Arizona.

The Picks: 

  • Go ahead and take the St. Louis Cardinals as your moneyline betting selection in this game.
  • Take the over on the implied run total in this one.
  • Roll with the St. Louis Cardinals -1.5 as the road favorites to cover the run line.

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