The San Francisco Giants (4th in NL West) look to complete a series sweep against the visiting Chicago Cubs (5th in NL Central) in a matchup at Oracle Park on Wednesday night. The Giants are favored on the money line (-130) after dominating the first MLB game of the series.

  • Giants Favored at Home: San Francisco (-130) looks to complete a series sweep against a slumping Chicago team (+109).
  • Rookie Pitching Duel: Hayden Wesneski (Cubs) and Hayden Birdsong (Giants – making his MLB debut) take the mound at Oracle Park (9:45 PM ET, MARQ).
  • Can Cubs Snap Losing Streak? Chicago has dropped three straight, while the Giants have won two in a row.
  • High-Scoring Affair or Pitching Showcase? The over/under line is set at 7.5 runs.

Here is a look at some Cubs vs Giants betting analysis that should help you make winnings MLB picks for this game.

Cubs vs Giants Odds

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Explore Cubs vs Giants Betting Picks on legal online sports betting platforms.

Overall Game Info & Outlook

  • Chicago Cubs at San Francisco Giants
  • The Cubs come into this matchup with an overall record of 37-43.
  • The Giants come into this matchup with an overall record of 38-42.

Chicago Cubs at San Francisco Giants Betting Preview

  • San Francisco Dominates: The Giants kick off the series with a convincing 5-1 victory over Chicago.
  • Big Second Inning Propels Offense: A productive 2nd inning fuels the Giants’ scoring, with key RBIs from Matos and Chapman.
  • Wisely Leads the Charge: Outfielder Brett Wisely goes 2-for-4 in the MLB Standings with a homer and an RBI, pacing the San Francisco attack.

Struggling Cubs Aim to Avoid Sweep in San Francisco

  • Downward Spiral: Chicago (37-43) looks to snap a three-game losing streak and avoid a series sweep against the Giants.
  • NL Central Woes: The Cubs have struggled against divisional foes (9-17) and on the road (15-25).
  • Can They Find Their Stride? Despite a decent home record (22-18 in the MLB Stats), Chicago needs to turn things around away from Wrigley.

Inconsistent Giants Aim for Sweep Against Struggling Cubs (June 26th)

  • Hot at Home, Cold on the Road: San Francisco (38-42) boasts a strong home record (22-17) but struggles on the road (16-25).
  • Can They Extend Win Streak? The Giants have won two straight and aim for a series sweep against a slumping Cubs team.
  • High-Scoring Affair Possible? San Francisco averages over 9 runs per game and has a good over/under record (44-34).

Recommended Pick: Giants ML -130

There are a few ways you could look to bet on this Cubs vs. Giants matchup, but our top recommendation would be to take the Giants on the money line at -130. We actually have the Giants winning this one by a score of 6-5, so you could also look to take the over, as the line is currently sitting at 7.5 runs.

If you are looking for a starting pitcher to have a big day, you could look at the Giants’ starter, as we actually have him finishing with the most strikeouts of any pitcher on the day. As for the Cubs’ starter, he is projected to finish with just four strikeouts.

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