The San Francisco 49ers travel to face the Los Angeles Chargers in this heated west coast matchup between talented teams as they get geared up for the NFL season.

San Francisco 49ers vs. Los Angeles Chargers Betting Preview

Our preseason week two Sunday night football game will see the San Francisco 49ers heading to Los Angeles to take on the Chargers. Kick-off for this game is scheduled for 7:30 pm eastern.

Both teams had disappointing 2020 seasons, with the 49ers finishing 6-10 while the Chargers ended 7-9. Neither team was able to make the playoffs. The biggest difference in seasons is the 49ers lost their starting quarterback to an injury early. The Chargers were able to have their rookie franchise quarterback play all season.

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The 49ers are in a tough spot as they have three quarterbacks who could start week one. They have their veteran, their rookie, and their mid-tier. The 49ers are in a spot where every preseason game is important.

The Chargers, who have their quarterback, will approach preseason a little differently. Instead of worrying about who will start game one of the regular season, the Chargers are focused on the guys at the backend, trying to make sure their 53rd guy is someone that they think can help them.

If knowing the Chargers starters are not going to play, so San Francisco should be heavily favorited, makes you decide you want to bet on this game, head over to Online Betting Sports

When it comes to the NFL odds, the San Francisco moneyline is at -240, and the Chargers are at +200. The 49ers are 5.5 point favorites at -110. The total points are set at 34, with the odds being at -110 for both the over and the under.

Who Will be the QB1 for the 49ers?

As the lead man, the 49ers have Jimmy Garoppolo. An injury-filled career as a starter, Garoppolo has all the tools to be a solid quarterback in the league. He just has to find a way to stay on the field. On the backside of the quarterback room, they have Trey Lance. A rookie quarterback who was drafted by the 49ers with the third pick overall. 


The third quarterback in the room is Nate Sudfeld. It would be an absolute stretch to see Sudfeld in the starting role and will probably spend more time on the practice squad. The 49ers will have most of their starters on the defensive side returning for 2021. They were a top-ten defensive team and looked to continue their dominance.

Will the Chargers Defense Keep Anyone Out of the Endzone

Yes, the Chargers ran a rookie quarterback out on the offensive side of the ball all season. No, he was not the greatest quarterback in his rookie year. He was able to lead the offense to 24 points per game, which kept his offense outside the bottom ten in the league for points scored.

The defense, however, gave up 26 points per game and was in the bottom 10 in that category. While the offseason could have been used to try and bolster the defense, the Chargers went a different route. The Chargers revamped their entire offensive line and will try to make sure they can keep their QB1, Justin Herbert, healthy and playing.

49ers Win

Without Herbert under center, the Chargers will send out Chase Daniel and Easton Stick. While both quarterbacks are viable options at a time of need, going against a team that is still working to find their quarterback will be a little more complicated.

The 49ers have to use this second game to solidify what they are going to do going forward. If they do not have a starter before week three of the preseason, that makes that last week of training camp much more stressful.

The Picks

When making your NFL picks, make sure to head over to Online Betting Sports

  • San Francisco Moneyline | -240
  • San Francisco -5.5 | -110
  • Under 34 | -110

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